English: FIGURE 2.

Statistical parametric maps of BPND of 11C-(R)-PK11195 in CFS/ME patients and healthy controls. Anatomic locations were mapped on template brains. Peak coordinates (−6, −22, −4) correspond to intralaminar nucleus of left thalamus. BPND of this coordinate for each individual in CFS/ME and HC groups is plotted in bottom right panel. ***P < 0.0001 (Student t test). HC = healthy control.

The SPM analysis also revealed significantly higher 11C-(R)-PK11195 BPND in CFS/ME patients than in healthy controls in the left thalamus, midbrain, and pons (Fig. 2). The Montréal Neurologic Institute coordinates of peak 11C-(R)-PK11195 BPND (highest t score on SPM5) in the CFS/ME group corresponded to the intralaminar nucleus of the left thalamus (−6, −22, −4) and midbrain (−4, −30, −14). In the CFS/ME group, the peak value of 11C-(R)-PK11195 BPND in the left thalamic intralaminar nucleus (−6, −22, −4) was positively correlated with the cognitive impairment score (r = 0.86; P = 0.0028) and tended to be positively correlated with the VAS score for fatigue sensation (r = 0.63; P = 0.0683), and the peak value of 11C-(R)-PK11195 BPND in the midbrain (−4, −30, −14) was positively correlated with the cognitive impairment score (r = 0.72, P = 0.0293).