English: The area of the nodes is proportional to xi—the difference in expression level. The width of the edges represents the coupling strength wij in the protein interaction network. The color of the nodes represents our score and the numbers shows their order in this ranking. Panels A and B shows the result of two values of φ—a low value of φ (2% of the maximal possible) in A, and a high value of φ (98% of max). Low φ-values put an emphasis on the difference in expression level; high φ-values stress the proximity to other vertices with high score. We also assume η≫1.