English: For T4 lysozyme the large-scale motions for Level 1 and Level 2 (shown in Figure 6 of the main text) are shown here. Note that the motions here depict movements of the substrate binding regions very clearly. Also note that the motions in Level 2 show a pronounced opening of the binding cleft, as indicated by an increase in the order parameter (described in the text). The movies also highlight the two sub-domains as well as the relevant motions between the sub-domains that cause the opening and closing of the substrate binding pocket. (MPG)