English: Endocytic trafficking of DENV. DENV particle (red, surrounded by a white circle) that rapidly moves to a Rab5-positive early endosome (blue) on time point (A). The early endosome carrying the DENV particle acquires Rab7 (green) by merging with an intermediate Rab5- and Rab7-positive endosome (B). Subsequently, the endosome gradually accumulates more Rab7 (C) and gradually loses Rab5 (D). After merging of another large late endosome (E), the virus finally fuses from within the Rab7-positive late endosome (F). Real-time tracking was performed as described in the legend of Video S2 . The playback speed is 10× real-time.