English: PI3K Activity Is Not Required during the Early Cell Divisions Stage (1–8 h APF) A homozygous mutant cell for dp110 in the anterior dorsal nest was induced in the blastoderm by mitotic recombination and labeled with GFP (green) using the MARCM system. Wild-type cells were labeled by expression of a nuclear His2-YFP (red). The mutant cell undergoes the first cell cycles at normal rates and forms a clone composed of eight cells. Arrows point the synchronous entry in mitosis of the dp110 mutant cell and its wild-type neighbor.