M-59 is an east–west state trunkline highway that crosses the northern part of Metropolitan Detroit in the US state of Michigan. It runs between Howell at Interstate 96 (I-96) and I-94 on the Chesterfield–Harrison township line near the Selfridge Air National Guard Base. While primarily a multi-lane surface highway, it is a full freeway from just east of the Pontiac downtown near Opdyke Road to just east of the Mound Road/Merrill Road exit in Utica. The various surface highway segments are named either Highland Road, Huron Street or Hall Road, with the latter known as an area for shopping and dining. The rural sections west of Pontiac pass through Oakland County lake country crossing through two state recreational areas.

M-59 was first designated with the rest of the original state trunkline highway system by July 1, 1919 between Pontiac and Mt. Clemens. Extensions on both ends brought the termini as far as Howell and New Baltimore before the current termini were established in the 1960s. M-59 was expanded into a freeway in the late 1960s and early 1970s, with additional expansions in the 1980s and 1990s to create the divided highway sections.

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