U.S. Route 264 is an east–west United States highway that runs for 215.7 miles (347.1 km) from Raleigh to Manns Harbor, entirely in the U.S. state of North Carolina.

U.S. Route 264 begins at the Raleigh Beltline (which carries US 64 and Interstate 440) and travels to the east from a directional T interchange, concurrently with US 64 along with it on a freeway alignment. It meets the eastern terminus of Interstate 540, which features several unused stub ramps. The route curves to the northeast, paralleling NC 97, until it passes by Zebulon. At the north side of town, US 64 continues to the northeast, while the US 264 freeway continues east through a long wooded stretch. It curves to the south just before it meets Interstate 95/Interstate 795, just west of Wilson.

As the freeway loops south of Wilson, the short concurrency of Interstate 795 splits-off towards Goldsboro as US 264 continues east to Greenville. In Greenville, the freeway downgrades to expressway grade at the US 13/NC 11/NC 903 interchange. After completing the loop north around Greenville, it continues east, on Pactolus Highway, through a largely developed area and passes through Washington and US 17.

The route continues east on a two-lane road, cutting through mostly farmland. It begins to curve to the northeast after meeting NC 99, entering Pantego on Main Street. Within the town, it curves to the east again and then south toward Belhaven, where it bypasses north of town while US 264 Business goes through it. After Belhaven, US 264 continues eastward once again entering Hyde county, passing south of Lake Mattamuskeet through an area dominated by farmland and through the community of Engelhard. Turning north, US 264 goes through the Alligator River National Wildlife Refuge before finally reaching Manns Harbor, where US 264 ends at intersection with US 64.

Pamlico Scenic Byway is an 127-mile (204 km) byway from Washington to Manns Harbor. US 264 overlap several sections of the byway. The byway is noted for its history, scenic views, and the three national wildlife refuges that the route goes through. Other roads and highways that make-up the byway are: NC 32, NC 45, NC 92, and NC 94.

en.wikipedia.org/wiki/U.S._Route_264